5d30 Southwestern University: Profile

Chemistry & Biochemistry

Lynn Guziec

Assistant Professor of Chemistry and Bio Chemistry

Areas of expertise
Synthetic Organic Chemistry.  The Design and Preparation of Anti-cancer compounds

Education

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Positions



January 01, 2010 - present
Southwestern University - Department of Chemistry Visiting Professor: 2007-2008 Part-time Assistant Professor: 1996-2007 University of Manitoba, Winnipeg, Manitoba, Canada ? Dept. of Pharmacy: Visiting Professor, 2004 1998 ? 2003 Contr

Teaching Philosophy


Previous Courses

Organic Chemistry Laboratory, Organic Chemistry Laboratory for Majors, Chemistry Appreciation: The Chemistry of the Human Body

Research

Synthetic Organic Chemistry. The Design and Preparation of Anti-cancer compounds.

Currently the Principal Investigator on 2 National Institutes of Health Grants


Publications

32 Publications in Scientific Journals

Some Recent Representative Papers: Student co-authors underlined

A. Begleiter, N. El-Gabalawy, L. Lange, M. Leith, L. Guziec, F. Guziec, ?A Model for NAD(P)H: Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy,? Drug Target Insights, 2009, 4, 1-8.

B. B. Hasinoff, H. Liang, X. Wu, L. J. Guziec, F. S. Guziec Jr., Kyle Marshall, J.C. Yalowich,   ?The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds,? Bioorg. Med. Chem., 2008, 16, 3959-3968.

S. I. Smith, L.J. Guziec,  F.S. Guziec, Jr., B. B. Hasinoff, J. S. Brodbelt, ?Evaluation of relative DNA binding affinities of anthrapyrazoles by electrospray ionization mass spectrometry,? J. Mass Spectrom., 2007, 42, 681-688. 

           

H. Liang, X. Wu, L. J. Guziec, F. S. Guziec Jr., K. K. Larson,  J. Lang,  J. C. Yalowich, B. B. Hasinoff,  ?A 3D-QSAR study of anthrapyrazole analogs of the anticancer agents losoxantrone and piroxantrone,? Journal of Chemical Information and Modeling, 2006 , 46, 1827-1835.

 


Honors & Awards

Currently Dr. Guziec Principal Investigator on 2 National Institutes of Health Grants

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