Areas of expertiseSynthetic Organic Chemistry. The Design and Preparation of Anti-cancer compounds
January 01, 2010 - present
Southwestern University - Department of Chemistry Visiting Professor: 2007-2008 Part-time Assistant Professor: 1996-2007 University of Manitoba, Winnipeg, Manitoba, Canada ? Dept. of Pharmacy: Visiting Professor, 2004 1998 ? 2003 Contr
Organic Chemistry Laboratory, Organic Chemistry Laboratory for Majors, Chemistry Appreciation: The Chemistry of the Human Body
Synthetic Organic Chemistry. The Design and Preparation of Anti-cancer compounds.
Currently the Principal Investigator on 2 National Institutes of Health Grants
32 Publications in Scientific Journals
Some Recent Representative Papers: Student co-authors underlined
A. Begleiter, N. El-Gabalawy, L. Lange, M. Leith, L. Guziec, F. Guziec, ?A Model for NAD(P)H: Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy,? Drug Target Insights, 2009, 4, 1-8.
B. B. Hasinoff, H. Liang, X. Wu, L. J. Guziec, F. S. Guziec Jr., Kyle Marshall, J.C. Yalowich, ?The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds,? Bioorg. Med. Chem., 2008, 16, 3959-3968.
S. I. Smith, L.J. Guziec, F.S. Guziec, Jr., B. B. Hasinoff, J. S. Brodbelt, ?Evaluation of relative DNA binding affinities of anthrapyrazoles by electrospray ionization mass spectrometry,? J. Mass Spectrom., 2007, 42, 681-688.
H. Liang, X. Wu, L. J. Guziec, F. S. Guziec Jr., K. K. Larson, J. Lang, J. C. Yalowich, B. B. Hasinoff, ?A 3D-QSAR study of anthrapyrazole analogs of the anticancer agents losoxantrone and piroxantrone,? Journal of Chemical Information and Modeling, 2006 , 46, 1827-1835.
Honors & Awards
Currently Dr. Guziec Principal Investigator on 2 National Institutes of Health Grants